PT  - JOURNAL ARTICLE
AU  - NAOYA ISHIBASHI
AU  - TOSHIYA MAEBAYASHI
AU  - MASAKUNI SAKAGUCHI
AU  - TAKUYA AIZAWA
AU  - YOSHIHITO UCHINO
AU  - MASAHARU HATA
AU  - MASAHIRO OKADA
TI  - Myelosuppression After Radiation Therapy in Patients With and Without Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Observational Study
AID  - 10.21873/anticanres.13330
DP  - 2019 Apr 01
TA  - Anticancer Research
PG  - 2163--2167
VI  - 39
IP  - 4
4099  - http://ar.iiarjournals.org/content/39/4/2163.short
4100  - http://ar.iiarjournals.org/content/39/4/2163.full
SO  - Anticancer Res2019 Apr 01; 39
AB  - Background/Aim: Autologous hematopoietic stem cell transplantation (ASCT) after high-dose chemotherapy is used to treat relapsed malignant lymphomas. Radiation therapy (RT) is applied after ASCT. We compared the incidence of myelosuppression after RT with and without autologous peripheral blood stem cell transplantation (auto-PBSCT). Patients and Methods: We retrospectively analyzed 20 patients with malignant lymphomas who received RT, six of whom underwent auto-PBSCT. Univariate analysis using Pearson's Chi-squared test and multivariate analysis using the Cox proportional hazards regression model were performed to determine correlations between the development of grade two or more leukopenia and clinical factors. Results: Among patients with auto-PBSCT, grade two or more leukopenia occurred in five. The incidence of grade two or more leukopenia was significantly higher in patients with auto-PBSCT than in those without (p=0.014). Conclusion: Hematopoietic functions after auto-PBSCT may be more vulnerable to RT than normal hematopoietic functions.