RT Journal Article
SR Electronic
T1 Revisiting the Prognostic Impact of Family History in Colorectal Cancer by Retrospective Propensity Score Matching
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5167
OP 5172
DO 10.21873/anticanres.16717
VO 43
IS 11
A1 MIZUUCHI, YUSUKE
A1 TANABE, YOSHITAKA
A1 NAGAYOSHI, KINUKO
A1 TAMURA, KOJI
A1 FUJIMOTO, TAKAAKI
A1 HISANO, KYOKO
A1 ZHANG, JINGHUI
A1 NAGAI, SHUNTARO
A1 NAKATA, KOHEI
A1 OHUCHIDA, KENOKI
A1 NAKAMURA, MASAFUMI
YR 2023
UL http://ar.iiarjournals.org/content/43/11/5167.abstract
AB Background/Aim: Family history of colorectal cancer (CRC) is a known risk factor for CRC. However, its prognostic value in patients with CRC remains controversial. This study aimed to clarify the prognostic impact of a family history of CRC. Patients and Methods: We retrospectively reviewed the database from 1978 to 2018 and enrolled 3,655 consecutive patients with CRC. We investigated the clinicopathological factors of patients with CRC with and without a family history. After propensity score matching, we performed a survival analysis of patients with CRC with and without a family history. Results: Patients with CRC with a family history of CRC had a young onset (63.2 and 65.9; p<0.001), were more likely to be female (54.3% and 49.7%; p=0.042), had less symptomatic disease (76.9% and 80.8%; p=0.008), were more likely to have right-sided colon cancer (27.5% and 26.1%), and had less distant metastases (11.3% and 14.9%; p=0.023) and multiple CRCs (10.2% and 7.8%) compared with those without a family history of CRC. Prior to propensity score matching, CRC-specific survival analysis showed that a family history of CRC was a good prognostic factor (p=0.022). After propensity score matching, survival curves overlapped between the two groups. Conclusion: Patients with CRC with a family history of CRC had specific clinicopathological features including younger onset, female sex, proximal colon location, fewer symptoms, smaller number of distant metastases, likelihood of multiple diseases, and earlier cancer stage. Family history of CRC in patients with CRC was not a prognostic factor.