RT Journal Article
SR Electronic
T1 Intraoperative Blood Loss Impacts Recurrence and Survival in Patients With Locally Advanced Esophageal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5173
OP 5179
DO 10.21873/anticanres.16718
VO 43
IS 11
A1 WATANABE, HAYATO
A1 KANO, KAZUKI
A1 HASHIMOTO, ITARU
A1 TANABE, MIE
A1 ONUMA, SHIZUNE
A1 MORITA, JUNYA
A1 NAGASAWA, SHINSUKE
A1 KANEMATSU, KYOHEI
A1 AOYAMA, TORU
A1 YAMADA, TAKANOBU
A1 OGATA, TAKASHI
A1 RINO, YASUSHI
A1 SAITO, AYA
A1 OSHIMA, TAKASHI
YR 2023
UL http://ar.iiarjournals.org/content/43/11/5173.abstract
AB Background/Aim: Intraoperative blood loss (IBL) has been reported to decrease survival after surgical resection of some malignancies; however, there are few reports on the effects of IBL on recurrence and survival in locally advanced esophageal cancer. Therefore, we investigated the relationship between IBL and postoperative recurrence and overall survival in patients who underwent surgery for esophageal cancer. Patients and Methods: One hundred and ninety-eight patients with locally advanced esophageal cancer who underwent preoperative adjuvant chemotherapy and curative resection as standard treatment were included in this study. Based on a defined cut-off value for IBL, 27 and 171 patients were classified into the high and low IBL groups, respectively. The relationship between each group and clinicopathological factors, postoperative recurrence, and overall survival were investigated. Results: In terms of the relationship between IBL and clinicopathological factors, the high IBL group had significantly more patients with pathological T4, longer operative time, and higher incidence of postoperative complications than the low IBL group. Both recurrence-free and overall survival were significantly worse in the high IBL group than in the low IBL group. Furthermore, multivariate analysis identified high IBL as an independent factor for predicting poor reference free survival and overall survival. Conclusion: Heavy IBL in patients with locally advanced esophageal cancer may be a useful predictor of postoperative recurrence and overall survival.