RT Journal Article
SR Electronic
T1 Outcomes and Prognostic Analysis of Surgical Resection for Oligometastasis from Hepatocellular Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5189
OP 5196
DO 10.21873/anticanres.16720
VO 43
IS 11
A1 OSHITA, KO
A1 KOBAYASHI, TSUYOSHI
A1 TADOKORO, TAKESHI
A1 NAMBA, YOSUKE
A1 FUKUHARA, SOTARO
A1 MATSUBARA, KEISO
A1 TAKEI, DAISUKE
A1 HONMYO, NARUHIKO
A1 KURODA, SHINTARO
A1 KAWAOKA, TOMOKAZU
A1 AIKATA, HIROSHI
A1 OHDAN, HIDEKI
YR 2023
UL http://ar.iiarjournals.org/content/43/11/5189.abstract
AB Background/Aim: This study aimed to evaluate the outcomes of patients who underwent resection for oligometastasis from hepatocellular carcinoma (HCC) and identify the prognostic factors associated with poor survival. Patients and Methods: Patients who underwent resection for oligometastasis from HCC between January 2000 and April 2021 were retrospectively investigated. Oligometastasis was defined as 1-5 single organ metastases that were detected preoperatively in this study. Clinical characteristics and treatment outcomes were analyzed, and independent risk factors for poor prognosis were identified using cox proportional hazards model. Results: A total of 33 patients were included in this study. Eleven oligometastases were located in the intraabdominal lymph node, 8 in the adrenal gland, 5 in the lung, 4 in the peritoneum, 3 in the pleura, and 1 each in the supraclavicular lymph node and abdominal wall. No re-operation or operative death occurred in this study. The median OS was 44.6 months (range=5.1-150.6 months), and the median survival after primary HCC diagnosis was 116.5 months (range=7.1-253.6 months). The median cumulative incidence of recurrent HCC was 7.2 months (range=0.3-94.7 months). The multivariate analysis showed that an alpha-fetoprotein level ≥20 ng/ml and multiple primary HCC tumors were independent poor prognostic factors. Conclusion: Clinical characteristics and treatment outcomes of patients who underwent resection for oligometastasis from HCC were demonstrated. A high alpha-fetoprotein level and multiple primary HCC tumors were independent poor prognostic factors. Surgical resection can be one of the treatment options for oligometastasis from HCC.