RT Journal Article SR Electronic T1 Outcomes and Prognostic Analysis of Surgical Resection for Oligometastasis from Hepatocellular Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5189 OP 5196 DO 10.21873/anticanres.16720 VO 43 IS 11 A1 KO OSHITA A1 TSUYOSHI KOBAYASHI A1 TAKESHI TADOKORO A1 YOSUKE NAMBA A1 SOTARO FUKUHARA A1 KEISO MATSUBARA A1 DAISUKE TAKEI A1 NARUHIKO HONMYO A1 SHINTARO KURODA A1 TOMOKAZU KAWAOKA A1 HIROSHI AIKATA A1 HIDEKI OHDAN YR 2023 UL http://ar.iiarjournals.org/content/43/11/5189.abstract AB Background/Aim: This study aimed to evaluate the outcomes of patients who underwent resection for oligometastasis from hepatocellular carcinoma (HCC) and identify the prognostic factors associated with poor survival. Patients and Methods: Patients who underwent resection for oligometastasis from HCC between January 2000 and April 2021 were retrospectively investigated. Oligometastasis was defined as 1-5 single organ metastases that were detected preoperatively in this study. Clinical characteristics and treatment outcomes were analyzed, and independent risk factors for poor prognosis were identified using cox proportional hazards model. Results: A total of 33 patients were included in this study. Eleven oligometastases were located in the intraabdominal lymph node, 8 in the adrenal gland, 5 in the lung, 4 in the peritoneum, 3 in the pleura, and 1 each in the supraclavicular lymph node and abdominal wall. No re-operation or operative death occurred in this study. The median OS was 44.6 months (range=5.1-150.6 months), and the median survival after primary HCC diagnosis was 116.5 months (range=7.1-253.6 months). The median cumulative incidence of recurrent HCC was 7.2 months (range=0.3-94.7 months). The multivariate analysis showed that an alpha-fetoprotein level ≥20 ng/ml and multiple primary HCC tumors were independent poor prognostic factors. Conclusion: Clinical characteristics and treatment outcomes of patients who underwent resection for oligometastasis from HCC were demonstrated. A high alpha-fetoprotein level and multiple primary HCC tumors were independent poor prognostic factors. Surgical resection can be one of the treatment options for oligometastasis from HCC.