RT Journal Article SR Electronic T1 Outcomes and Prognostic Analysis of Surgical Resection for Oligometastasis from Hepatocellular Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5189 OP 5196 DO 10.21873/anticanres.16720 VO 43 IS 11 A1 OSHITA, KO A1 KOBAYASHI, TSUYOSHI A1 TADOKORO, TAKESHI A1 NAMBA, YOSUKE A1 FUKUHARA, SOTARO A1 MATSUBARA, KEISO A1 TAKEI, DAISUKE A1 HONMYO, NARUHIKO A1 KURODA, SHINTARO A1 KAWAOKA, TOMOKAZU A1 AIKATA, HIROSHI A1 OHDAN, HIDEKI YR 2023 UL http://ar.iiarjournals.org/content/43/11/5189.abstract AB Background/Aim: This study aimed to evaluate the outcomes of patients who underwent resection for oligometastasis from hepatocellular carcinoma (HCC) and identify the prognostic factors associated with poor survival. Patients and Methods: Patients who underwent resection for oligometastasis from HCC between January 2000 and April 2021 were retrospectively investigated. Oligometastasis was defined as 1-5 single organ metastases that were detected preoperatively in this study. Clinical characteristics and treatment outcomes were analyzed, and independent risk factors for poor prognosis were identified using cox proportional hazards model. Results: A total of 33 patients were included in this study. Eleven oligometastases were located in the intraabdominal lymph node, 8 in the adrenal gland, 5 in the lung, 4 in the peritoneum, 3 in the pleura, and 1 each in the supraclavicular lymph node and abdominal wall. No re-operation or operative death occurred in this study. The median OS was 44.6 months (range=5.1-150.6 months), and the median survival after primary HCC diagnosis was 116.5 months (range=7.1-253.6 months). The median cumulative incidence of recurrent HCC was 7.2 months (range=0.3-94.7 months). The multivariate analysis showed that an alpha-fetoprotein level ≥20 ng/ml and multiple primary HCC tumors were independent poor prognostic factors. Conclusion: Clinical characteristics and treatment outcomes of patients who underwent resection for oligometastasis from HCC were demonstrated. A high alpha-fetoprotein level and multiple primary HCC tumors were independent poor prognostic factors. Surgical resection can be one of the treatment options for oligometastasis from HCC.