RT Journal Article
SR Electronic
T1 Up-regulation of Hypoxia-inducible Factor-1 Alpha and VEGF mRNAs in Peritoneal Dissemination of Patients with Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3849
OP 3853
VO 26
IS 5B
A1 YOSHIKAWA, TAKAKI
A1 TSUBURAYA, AKIRA
A1 MIYAGI, YOHEI
A1 SEKIGUCHI, HIRONOBU
A1 KIMURA, MASAYUKI
A1 CHO, HARUHIKO
A1 KOBAYASHI, OSAMU
YR 2006
UL http://ar.iiarjournals.org/content/26/5B/3849.abstract
AB Background: Gastric cancer often metastasizes to the peritoneal cavity in which tumor cells are exposed to hypoxia without systemic circulation. Hypoxia-inducible factor-1 (HIF-1) and its target gene, vascular endothelial growth factor (VEGF), may play a role in the development of peritoneal metastases. Materials and Methods: The mRNA levels of HIF-1 alpha and VEGF were examined in 21 normal gastric mucosa, 158 primary tumors and 18 peritoneal metastases by quantitative RT-PCR. Results: HIF-1 alpha and VEGF were significantly up-regulated in the peritoneal metastases compared with those of the normal mucosa and the primary tumors. A positive correlation between HIF-1 alpha and VEGF was observed in the peritoneal dissemination. Conclusion: These results suggest that HIF-1 alpha and its target gene, VEGF, were up-regulated in the intraperitoneal tumors but not in the primary cancers of the stomach. Different microenvironments may influence the expressions of these genes.