%0 Journal Article %A CHRISTOF M. KRAMM %A SABINE WAGNER %A STEFAN VAN GOOL %A HANSJÖRG SCHMID %A RONALD STRÄTER %A ASTRID GNEKOW %A STEFAN RUTKOWSKI %A JOHANNES E. A. WOLFF %T Improved Survival after Gross Total Resection of Malignant Gliomas in Pediatric Patients from the HIT-GBM Studies %D 2006 %J Anticancer Research %P 3773-3779 %V 26 %N 5B %X The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From the HIT-GBM data base of the Gesellschaft für Paediatrische Onkologie und Haematologie (GPOH), 85 pediatric patients with malignant non-pontine gliomas were analyzed. Histological diagnosis and extent of tumor resection had been confirmed by central neuropathological review and post-surgical imaging. The extent of tumor resection represented the most prominent prognostic factor for overall (OS) and event-free survival (EFS) in univariate and Cox regression analyses. Four-year survival after gross total tumor resection was 48.0±12.0% (OS) and 14.1±8.9% (EFS), after non-total resection 13.2±6.1% and 2.9±2.8%, respectively. From several clinical parameters, only histological grading displayed a similar statistical significance in Cox regression analysis. In conclusion, gross total tumor resection improves survival in pediatric patients with malignant gliomas and should always be attempted when possible. %U https://ar.iiarjournals.org/content/anticanres/26/5B/3773.full.pdf