PT  - JOURNAL ARTICLE
AU  - HAN, DONG HOON
AU  - LEE, MIN JEON
AU  - KIM, JEONG HEE
TI  - Antioxidant and Apoptosis-inducing Activities of Ellagic Acid
DP  - 2006 Sep 01
TA  - Anticancer Research
PG  - 3601--3606
VI  - 26
IP  - 5A
4099  - http://ar.iiarjournals.org/content/26/5A/3601.short
4100  - http://ar.iiarjournals.org/content/26/5A/3601.full
SO  - Anticancer Res2006 Sep 01; 26
AB  - Background: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. Materials and Methods: DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. Results: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. Bax expression was induced and caspase-3 was activated by ellagic acid treatment. Conclusion: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved