RT Journal Article
SR Electronic
T1 Expressions of MMP-2, MMP-9 and VEGF are Closely Linked to Growth, Invasion, Metastasis and Angiogenesis of Gastric Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3579
OP 3583
VO 26
IS 5A
A1 ZHENG, HUACHUAN
A1 TAKAHASHI, HIROYUKI
A1 MURAI, YOSHIHIRO
A1 CUI, ZHENGGUO
A1 NOMOTO, KAZUHIRO
A1 NIWA, HIDEKI
A1 TSUNEYAMA, KOICHI
A1 TAKANO, YASUO
YR 2006
UL http://ar.iiarjournals.org/content/26/5A/3579.abstract
AB Background: Gastric carcinoma is still a major leading cause of cancer death in East Asia. Since angiogenesis is a necessary condition for invasion and metastasis, its regulation is of essential significance. Materials and Methods: Expressions of MMP-2, MMP-9 and VEGF were examined with microarray of gastric carcinoma tissue samples (n=249) by immunostaining. In addition, microvessel density (MVD) was assessed after labelling with the anti-CD34 antibody. Data were cross-compared with clinicopathological parameters of tumors, including PTEN expression. Results: Expressions of MMP-2, MMP-9 and VEGF were positively correlated with tumour size, depth of invasion, lymphatic and venous invasion, lymph node metastasis, UICC staging and MVD of gastric carcinomas (p<0.05). VEGF expression was positively linked with levels of MMP-2 and MMP-9 (p<0.05), but negatively with PTEN (p<0.05). The latter was also inversely associated with the MVD in gastric carcinomas (p<0.05). Conclusion: MMP-2, MMP-9 and VEGF largely contribute to the angiogenesis and progression of gastric carcinomas. PTEN might inhibit the processes by down-regulating VEGF expression. These parameters should be regarded as good markers to indicate pathobiological behaviours of gastric carcinomas. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved