RT Journal Article
SR Electronic
T1 Epidermal Growth Factor Receptor (EGFR): Mutational and Protein Expression Analysis in Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3547
OP 3550
VO 26
IS 5A
A1 ENZO MAMMANO
A1 CLAUDIO BELLUCO
A1 MANUELA SCIRO
A1 ROBERTO MENCARELLI
A1 MARCO AGOSTINI
A1 MAURO MICHELOTTO
A1 ALBERTO MARCHET
A1 DONATO NITTI
YR 2006
UL http://ar.iiarjournals.org/content/26/5A/3547.abstract
AB Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved