RT Journal Article
SR Electronic
T1 Improvement of Medication Guidance Sheet for Total Body Irradiation/Cyclophosphamide Followed by Allogeneic Hematopoietic Stem Cell Transplantation Based on Real Monitoring Data
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4067
OP 4075
DO 10.21873/anticanres.16596
VO 43
IS 9
A1 MAYAKO UCHIDA
A1 SHIGERU ISHIDA
A1 ERIKA MOCHIZUKI
A1 NANA OZAWA
A1 HIROKO YONEMITSU
A1 HIDEKI OCHIAI
A1 HANAE NAKAMURA
A1 TAKEHIRO KAWASHIRI
A1 KOJI KATO
A1 NOBUAKI EGASHIRA
A1 KOICHI AKASHI
A1 ICHIRO IEIRI
YR 2023
UL http://ar.iiarjournals.org/content/43/9/4067.abstract
AB Background/Aim: Adverse events (AEs) must be managed during cancer therapy. We had previously developed a medication guidance sheet (MGS) to monitor AEs after conditioning therapy with allogeneic hematopoietic stem cell transplantation (HSCT). However, it remains unclear whether this sheet can accurately predict the type, onset, and duration of AEs in clinical practice. In this study, we evaluated the clinical utility of the original MGS in patients receiving total body irradiation (TBI) and cyclophosphamide (CY). Patients and Methods: Fifty-eight patients who underwent TBI/CY were included. The types, onsets, and durations of AEs observed during real monitoring were compared with those listed in the original MGS. Results: A total of 361 subjective AE symptoms were observed, all of which were predictive, as listed in the MGS. However, the durations of several AEs were longer than expected. Thus, the prediction accuracy for all AEs was 67.0%. The accuracy rate was the lowest for anorexia (6.7%), followed by diarrhea (42.6%), and nausea/vomiting (55.6%). Acute graft versus host disease (GVHD) most likely caused the prolongation of AEs. Subsequently, the original MGS was revised to account for the possible occurrence of acute GVHD. Conclusion: When monitoring AEs in patients receiving a TBI/CY conditioning regimen for HSCT, the involvement of acute GVHD-associated AEs should be considered. In this respect, the present modified MGS is particularly useful for rapid and accurate monitoring of AEs.