PT  - JOURNAL ARTICLE
AU  - MAYAKO UCHIDA
AU  - SHIGERU ISHIDA
AU  - ERIKA MOCHIZUKI
AU  - NANA OZAWA
AU  - HIROKO YONEMITSU
AU  - HIDEKI OCHIAI
AU  - HANAE NAKAMURA
AU  - TAKEHIRO KAWASHIRI
AU  - KOJI KATO
AU  - NOBUAKI EGASHIRA
AU  - KOICHI AKASHI
AU  - ICHIRO IEIRI
TI  - Improvement of Medication Guidance Sheet for Total Body Irradiation/Cyclophosphamide Followed by Allogeneic Hematopoietic Stem Cell Transplantation Based on Real Monitoring Data
AID  - 10.21873/anticanres.16596
DP  - 2023 Sep 01
TA  - Anticancer Research
PG  - 4067--4075
VI  - 43
IP  - 9
4099  - http://ar.iiarjournals.org/content/43/9/4067.short
4100  - http://ar.iiarjournals.org/content/43/9/4067.full
SO  - Anticancer Res2023 Sep 01; 43
AB  - Background/Aim: Adverse events (AEs) must be managed during cancer therapy. We had previously developed a medication guidance sheet (MGS) to monitor AEs after conditioning therapy with allogeneic hematopoietic stem cell transplantation (HSCT). However, it remains unclear whether this sheet can accurately predict the type, onset, and duration of AEs in clinical practice. In this study, we evaluated the clinical utility of the original MGS in patients receiving total body irradiation (TBI) and cyclophosphamide (CY). Patients and Methods: Fifty-eight patients who underwent TBI/CY were included. The types, onsets, and durations of AEs observed during real monitoring were compared with those listed in the original MGS. Results: A total of 361 subjective AE symptoms were observed, all of which were predictive, as listed in the MGS. However, the durations of several AEs were longer than expected. Thus, the prediction accuracy for all AEs was 67.0%. The accuracy rate was the lowest for anorexia (6.7%), followed by diarrhea (42.6%), and nausea/vomiting (55.6%). Acute graft versus host disease (GVHD) most likely caused the prolongation of AEs. Subsequently, the original MGS was revised to account for the possible occurrence of acute GVHD. Conclusion: When monitoring AEs in patients receiving a TBI/CY conditioning regimen for HSCT, the involvement of acute GVHD-associated AEs should be considered. In this respect, the present modified MGS is particularly useful for rapid and accurate monitoring of AEs.