RT Journal Article
SR Electronic
T1 Kinetics of MMP-1 and MMP-3 Produced by Mast Cells and Macrophages in Liver Fibrogenesis of Rat
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3517
OP 3526
VO 26
IS 5A
A1 WON-IL JEONG
A1 SUN-HEE DO
A1 DA-HEE JEONG
A1 IL-HWA HONG
A1 JIN-KYU PARK
A1 KI-MI RAN
A1 HAI-JIE YANG
A1 DONG-WEI YUAN
A1 SOON-BOK KIM
A1 MYUNG-SOOK CHA
A1 KYU-SHIK JEONG
YR 2006
UL http://ar.iiarjournals.org/content/26/5A/3517.abstract
AB Background: The involvement of whether macrophages and mast cells in the kinetics of matrix metalloproteinases-1 (MMP-1), MMP-3 and MMP-9, tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 in hepatic fibrosis/cirrhosis was examined. Materials and Methods: The MMPs and TIMPs were examined by histopathology, immunohistochemistry and immunoblotting using carbon tetrachloride-induced fibrotic rat liver. Results: MMP-1 increased in proportion to the development of fibrosis and reached maximum at week 14. In the first four weeks, MMP-3 expression was mainly observed in many hepatocytes. At week 8, the macrophages in the fibrous septa, as well as hepatocytes, expressed MMP-3. TIMP-1 and -2 progressively increased throughout the experimental periods. The MMP-1 expression in the mast cells, however, did not decrease the degree of liver cirrhosis. Conclusion: MMP-1, TIMP-1 and -2 expressions increased in the late stages of fibrosis and cirrhosis. During recovery, the MMP-3 expression of macrophages greatly increased in the unresolved fibrous septa. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved