RT Journal Article SR Electronic T1 Association of Matrix Metallopeptidase-2 Promoter Polymorphisms With the Risk of Childhood Leukemia JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1185 OP 1190 DO 10.21873/anticanres.13228 VO 39 IS 3 A1 PEI-CHEN HSU A1 JEN-SHENG PEI A1 CHAO-CHUN CHEN A1 WEN-SHIN CHANG A1 CHIEN-CHUNG KUO A1 SHUN-PING CHENG A1 CHIA-WEN TSAI A1 DA-TIAN BAU A1 CHI-LI GONG YR 2019 UL http://ar.iiarjournals.org/content/39/3/1185.abstract AB Background/Aim: The association of matrix metalloproteinase-2 (MMP-2) genotypes with adult leukemia has been reported only once, but never for childhood leukemia. This study aimed to determine the role of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes in childhood leukemia risk. Materials and Methods: This case–control study included 266 patients and 266 age- and gender-matched healthy controls. The polymorphic sites of MMP-2 were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism. Results: The CC, CT and TT of rs243865 genotype were 75.2, 23.7 and 1.1% in the case group and 69.2, 28.9 and 1.9% in the control group, respectively. The CT and TT genotypes caused a 0.75- and 0.55-fold increase in the risk of childhood leukemia, respectively. There was no differential distribution of rs2285053 genotypes. Allelic frequency analysis showed that the T allele of MMP-2 promoter -1306 and -735 conferred lower susceptibility than the C allele. Conclusion: The MMP-2 promoter genotypes play a minor role in determining personal susceptibility to childhood leukemia among the Taiwanese.