TY - JOUR T1 - Visualisation of Neuroblastoma Growth in a <em>Scid</em> Mouse Model Using [<sup>18</sup>F]FDG and [<sup>18</sup>F]FLT-PET JF - Anticancer Research JO - Anticancer Res SP - 3467 LP - 3472 VL - 26 IS - 5A AU - NINA KRIEGER-HINCK AU - HEIKE GUSTKE AU - URSULA VALENTINER AU - PAL MIKECZ AU - RALPH BUCHERT AU - JANOS MESTER AU - UDO SCHUMACHER Y1 - 2006/09/01 UR - http://ar.iiarjournals.org/content/26/5A/3467.abstract N2 - Background: Tumor therapy has been monitored using the metabolic indicator [18F]fluorodeoxyglucose ([18F]FDG). However, the nucleotide precursor [18F]fluoro-thymidine ([18F]FLT) is in principle more specific as it is incorporated into DNA. Thus, the [18F]FDG and [18F]FLT uptake by human neuroblastomas grown in Scid mice are compared in this study. Materials and Methods: Scid mice were inoculated with human neuroblastoma cells. Tumor imaging was performed with a human whole-body full-ring PET scanner. Furthermore, the tumor weight and the cell proliferation rate were determined. Results: Neuroblastomas could be visualised using [18F]FDG in 40% and with [18F]FLT in 70% of the cases. [18F]FDG or [18F]FLT uptake could not be visualised in neuroblastomas less than 1.0 g in weight. No correlation between the cell proliferation rate and tracer uptake could be detected. Conclusion: [18F]FLT showed a higher uptake than [18F]FDG and, therefore, might be more suitable for monitoring anticancer therapy, at least in this tumor model. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -