TY - JOUR T1 - Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells JF - Anticancer Research JO - Anticancer Res SP - 3429 LP - 3438 VL - 26 IS - 5A AU - KEUN-WOOK LEE AU - JEE HYUN KIM AU - JUNG-HYUN PARK AU - HWANG-PHILL KIM AU - SANG-HYUN SONG AU - SANG GYUN KIM AU - TAI YOUNG KIM AU - HYUN-SOON JONG AU - KYUNG HAE JUNG AU - SEOCK-AH IM AU - TAE-YOU KIM AU - NOE KYEONG KIM AU - YUNG-JUE BANG Y1 - 2006/09/01 UR - http://ar.iiarjournals.org/content/26/5A/3429.abstract N2 - Background: A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines. Materials and Methods: Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA). Results: SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G2/M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation. Conclusion: These results suggest that SK-7041 may have potential anticancer activity. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -