PT  - JOURNAL ARTICLE
AU  - KEUN-WOOK LEE
AU  - JEE HYUN KIM
AU  - JUNG-HYUN PARK
AU  - HWANG-PHILL KIM
AU  - SANG-HYUN SONG
AU  - SANG GYUN KIM
AU  - TAI YOUNG KIM
AU  - HYUN-SOON JONG
AU  - KYUNG HAE JUNG
AU  - SEOCK-AH IM
AU  - TAE-YOU KIM
AU  - NOE KYEONG KIM
AU  - YUNG-JUE BANG
TI  - Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells
DP  - 2006 Sep 01
TA  - Anticancer Research
PG  - 3429--3438
VI  - 26
IP  - 5A
4099  - http://ar.iiarjournals.org/content/26/5A/3429.short
4100  - http://ar.iiarjournals.org/content/26/5A/3429.full
SO  - Anticancer Res2006 Sep 01; 26
AB  - Background: A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines. Materials and Methods: Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA). Results: SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G2/M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation. Conclusion: These results suggest that SK-7041 may have potential anticancer activity. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved