RT Journal Article
SR Electronic
T1 Preoperative Osteopenia Is a Risk Factor for Death in Patients Undergoing Gastrectomy for Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3665
OP 3672
DO 10.21873/anticanres.16548
VO 43
IS 8
A1 SHIMIZU, SHOTA
A1 MATSUNAGA, TOMOYUKI
A1 SAWATA, SHOHEI
A1 SAKANO, YU
A1 MAKINOYA, MASAHIRO
A1 SHISHIDO, YUJI
A1 MIYATANI, KOZO
A1 KONO, YUSUKE
A1 MURAKAMI, YUKI
A1 HANAKI, TAKEHIKO
A1 KIHARA, KYOICHI
A1 YAMAMOTO, MANABU
A1 TOKUYASU, NARUO
A1 TAKANO, SHUICHI
A1 SAKAMOTO, TERUHISA
A1 HASEGAWA, TOSHIMICHI
A1 FUJIWARA, YOSHIYUKI
YR 2023
UL http://ar.iiarjournals.org/content/43/8/3665.abstract
AB Background/Aim: Preoperative osteopenia, defined as low bone mineral density (BMD), has been reported as a prognostic factor in patients with digestive tract cancers. However, the correlation between preoperative osteopenia and the prognosis of gastric cancer (GC) remains unclear. The aim of this study was to reveal the importance of preoperative osteopenia as a prognostic factor in patients undergoing gastrectomy for GC. Patients and Methods: We enrolled 251 patients who had undergone curative surgery for histopathologically diagnosed gastric adenocarcinoma from January 2008 to December 2012. BMD was calculated as the average pixel density (Hounsfield units) within a circle of the mid-vertebral core at the bottom of the 11th thoracic vertebra on preoperative computed tomography. Results: Osteopenia had a high area under the curve and predictive value for both overall survival (OS) and disease-specific survival (DSS). The study cohort was categorized into an osteopenia group and non-osteopenia group based on the optimal BMD cutoff values for OS (157.5) and DSS (195) determined by receiver operating characteristic analysis. The multivariate analysis revealed that OS (hazard ratio=3.607, p<0.001) and DSS (hazard ratio=2.797, p=0.03) were significantly worse in patients with than without preoperative osteopenia. Conclusion: Preoperative osteopenia is associated with poor OS and DSS in patients undergoing gastrectomy for GC.