PT - JOURNAL ARTICLE AU - MATSUOKA, HIROFUMI AU - NAKAMURA, KEIICHIRO AU - YORIMITSU, MASAE AU - OGAWA, MARIKO AU - KANEMORI, MIHO AU - SUEOKA, KOTARO AU - KOZAI, AYUMI AU - NAKAMURA, HIROKO AU - HARUMA, TOMOKO AU - SHIROYAMA, YUKO AU - HAYATA, YUU AU - SUGII, HIROKAZU AU - UEDA, AKIKO AU - KURIHARA, SHUICHI AU - URAYAMA, SAIKO AU - SHIMIZU, MIYUKI AU - MASUYAMA, HISASHI TI - Relationship Between Hematological Toxicities During Maintenance Treatment and During Chemotherapy Before Maintenance Treatment in Patients With Platinum-sensitive Relapsed Ovarian Cancer AID - 10.21873/anticanres.16546 DP - 2023 Aug 01 TA - Anticancer Research PG - 3653--3658 VI - 43 IP - 8 4099 - http://ar.iiarjournals.org/content/43/8/3653.short 4100 - http://ar.iiarjournals.org/content/43/8/3653.full SO - Anticancer Res2023 Aug 01; 43 AB - Background/Aim: To determine if maintenance treatment can be performed effectively and safely in patients with platinum-sensitive relapsed ovarian cancer. Patients and Methods: We carried out a multi-center study to investigate progression-free survival (PFS) and adverse events (AEs) in 229 patients receiving maintenance treatment for platinum-sensitive relapsed ovarian cancer. Results: The median PFS in the 229 patients with maintenance treatment was 14.0 months (95% confidence interval=10.3-17.6 months). The hematological toxicities included ≥grade 3 anemia in 33.2% of cases. Anemia during maintenance treatment was significantly more common than anemia during chemotherapy given before maintenance treatment (p<0.001). Anemia during chemotherapy prior to maintenance treatment significantly increased the risk of anemia during maintenance treatment, compared with other clinical features (p<0.001). Conclusion: Maintenance treatment can be performed safely and effectively in patients with platinum-sensitive relapsed ovarian cancer. Anemia during chemotherapy given before maintenance treatment significantly increased the risk of developing anemia during maintenance treatment in patients with platinum-sensitive relapsed ovarian cancer.