RT Journal Article
SR Electronic
T1 Aberrant Methylation is Frequently Observed in Advanced Esophageal Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3333
OP 3335
VO 26
IS 5A
A1 TOMOKI FUKUOKA
A1 KENJI HIBI
A1 AKIMASA NAKAO
YR 2006
UL http://ar.iiarjournals.org/content/26/5A/3333.abstract
AB The combined methylation status of the p16, helicase-like transcription factor (HLTF) and T-cadherin, H-cadherin (CDH13) genes in 35 resected primary esophageal squamous cell carcinoma (ESCC) was examined using methylation-specific PCR. To examine whether the methylation status could be a marker for the malignancy of ESCC, the methylation status was correlated with the clinicopathological features of the affected patients. Aberrant methylation of the p16, HLTF and CDH13 genes was detected in 28 (80%), one (3%) and five (14%) out of 35 ESCC specimens, respectively. ESCC with methylation-positive genes showed a trend towards larger tumor size and deeper invasion (p=0.139 and p=0.0664, respectively). Thus, the methylation of the p16, HLTF and CDH13 genes is a high malignancy factor in ESCC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved