RT Journal Article SR Electronic T1 C-MYC Locus Amplification as Metastasis Predictor in Intestinal-type Gastric Adenocarcinomas: CGH Study in Brazil JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2909 OP 2914 VO 26 IS 4B A1 BURBANO, ROMMEL RODRÍGUEZ A1 ASSUMPÇÃO, PAULO PIMENTEL A1 LEAL, MARIANA FERREIRA A1 CALCAGNO, DANIELLE QUEIROZ A1 GUIMARÃES, ADRIANA COSTA A1 KHAYAT, ANDRÉ SALIM A1 TAKENO, SYLVIA SATOMI A1 CHEN, ELIZABETH SUCHI A1 DE ARRUDA CARDOSO SMITH, MARÍLIA YR 2006 UL http://ar.iiarjournals.org/content/26/4B/2909.abstract AB Background: The genetic events involved in gastric cancer, the third most frequent cancer in the world with a high incidence in Pará State, Brazil, remain largely unknown. Materials and Methods: Twenty-one primary gastric adenocarcinomas were investigated by comparative genomic hybridization (CGH) and the relationships between genomic abnormalities and histopathological features were evaluated. Results: Eighty-one percent of cases presented DNA copy-number changes. Chromosomal gains were the most frequent finding, losses occurring only in the diffuse type. The main copy-number gains were on chromosome 8, principally on 8q24.1 (8/21 cases), 8p21 (3/21) and 8p23.2-8p12 (2/21). Gain of region 8q24.1, where C-MYC is located, was the main finding, exclusively in the intestinal type with metastasis. Conclusion: C-MYC locus amplification may be predictor of aggressiveness in intestinal-type gastric cancer, playing an important role in its development and progression. Moreover, other genes on 8q24 should be investigated. Gastric adenocarcinomas of differing histopathological features were associated with distinct genetic alterations, supporting the hypothesis that they evolve through distinct genetic pathways. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved