RT Journal Article
SR Electronic
T1 Local Delivery of Doxorubicin for Malignant Glioma by a Biodegradable PLGA Polymer Sheet
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3317
OP 3326
VO 26
IS 5A
A1 YOSHINOBU MANOME
A1 TOSHIAKI KOBAYASHI
A1 MARIKO MORI
A1 RIE SUZUKI
A1 NAOTAKE FUNAMIZU
A1 NOBUTAKE AKIYAMA
A1 SACHIKO INOUE
A1 YASUHIKO TABATA
A1 MICHIKO WATANABE
YR 2006
UL http://ar.iiarjournals.org/content/26/5A/3317.abstract
AB Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization to poly(D,L-lactide-co-glycolide) (PLGA). When release of the drug from the sheet was measured, sustained release continued until day 34. The data contrasted with the burst release from material containing a higher proportion of the drug. In terms of biodegradability, a subcutaneous 3 × 3-mm tetragonal sheet was almost completely absorbed by day 80. When a glioma was implanted subcuteneously and the tumor nodule exposed to the sheet, the device inhibited tumor growth significantly. The sheet consisted of an amorphous structure with cavities estimated to have a diameter of 0.5 - 3 μm by electron microscopic observation. Since the sheet is implantable, biodegradable and has a sustained-drug release property, the device may play a role in the local therapy of brain tumors. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved