PT - JOURNAL ARTICLE AU - YOSHINOBU MANOME AU - TOSHIAKI KOBAYASHI AU - MARIKO MORI AU - RIE SUZUKI AU - NAOTAKE FUNAMIZU AU - NOBUTAKE AKIYAMA AU - SACHIKO INOUE AU - YASUHIKO TABATA AU - MICHIKO WATANABE TI - Local Delivery of Doxorubicin for Malignant Glioma by a Biodegradable PLGA Polymer Sheet DP - 2006 Sep 01 TA - Anticancer Research PG - 3317--3326 VI - 26 IP - 5A 4099 - http://ar.iiarjournals.org/content/26/5A/3317.short 4100 - http://ar.iiarjournals.org/content/26/5A/3317.full SO - Anticancer Res2006 Sep 01; 26 AB - Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization to poly(D,L-lactide-co-glycolide) (PLGA). When release of the drug from the sheet was measured, sustained release continued until day 34. The data contrasted with the burst release from material containing a higher proportion of the drug. In terms of biodegradability, a subcutaneous 3 × 3-mm tetragonal sheet was almost completely absorbed by day 80. When a glioma was implanted subcuteneously and the tumor nodule exposed to the sheet, the device inhibited tumor growth significantly. The sheet consisted of an amorphous structure with cavities estimated to have a diameter of 0.5 - 3 μm by electron microscopic observation. Since the sheet is implantable, biodegradable and has a sustained-drug release property, the device may play a role in the local therapy of brain tumors. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved