PT  - JOURNAL ARTICLE
AU  - WILHELM ENGSTRÖM
AU  - MARIKA GRANERUS
TI  - Effects of Fibroblast Growth Factors 19 and 20 on Cell Multiplication and Locomotion in a Human Embryonal Carcinoma Cell Line (Tera-2) <em>In Vitro</em>
DP  - 2006 Sep 01
TA  - Anticancer Research
PG  - 3307--3310
VI  - 26
IP  - 5A
4099  - http://ar.iiarjournals.org/content/26/5A/3307.short
4100  - http://ar.iiarjournals.org/content/26/5A/3307.full
SO  - Anticancer Res2006 Sep 01; 26
AB  - Background: The effects of two recently discovered heparin binding growth factors, FGF-19 and FGF-20, on the human embryonal carcinoma derived cell line Tera 2 were examined. Materials and Methods: Cell numbers, as well as cell migration were examined at the clonal level by light microscopy. Results: FGF-19, as well as FGF-20 promoted Tera 2 cell multiplication. Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect. Moreover, FGF-19 did not significantly stimulate cell locomotion, while FGF-20 promoted cell motility at high doses. Conclusion: FGF-19 and FGF-20 qualitatively exert different effects on cell survival and cell locomotion. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved