RT Journal Article
SR Electronic
T1 Clinical Significance of Recurrence Risk Score for Conversion Surgery in Patients With Advanced Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3305
OP 3310
DO 10.21873/anticanres.16506
VO 43
IS 7
A1 ARIGAMI, TAKAAKI
A1 MATSUSHITA, DAISUKE
A1 SHIMONOSONO, MASATAKA
A1 TSURUDA, YUSUKE
A1 SASAKI, KEN
A1 BABA, KENJI
A1 WADA, MASUMI
A1 KUROSHIMA, NAOKI
A1 KURAHARA, HIROSHI
A1 OHTSUKA, TAKAO
YR 2023
UL http://ar.iiarjournals.org/content/43/7/3305.abstract
AB Background/Aim: To develop a recurrence risk score for determining the clinical indication for adjuvant chemotherapy in patients with initially unresectable advanced gastric cancer who underwent conversion surgery after chemotherapy. Patients and Methods: A total of 65 patients with stage IV gastric cancer who underwent conversion surgery after chemotherapy were retrospectively enrolled. We established a risk score based on clinicopathological factors related to recurrence after conversion surgery. Results: Out of 65 patients, 40 (62%) had recurrence after conversion surgery. The 5-year overall survival rates in patients with and without recurrence were 14.4% and 87.1%, respectively (p<0.01). Multivariate logistic regression analysis identified the depth of tumor invasion (pT2-4) and histological tumor response (grade 0-1a) as an independent risk factor for disease recurrence (p=0.033 and p=0.048, respectively). A scoring system determined by these two factors was created; total score ranged from 0 to 2 points, and patients were categorized into three groups (scores of 0 vs. 1 vs. 2 points). This scoring system showed that 12 (18%), 15 (23%), and 38 (58%) patients had recurrence risk scores of 0, 1, and 2 points, respectively. There was a close relationship between a high score and the presence of tumor recurrence (p<0.01). Moreover, our model system had a high sensitivity for the prediction of recurrence, compared with the pathological stage. Conclusion: Recurrence risk score is a promising tool for assessing the need for adjuvant chemotherapy in patients with initially unresectable advanced gastric cancer after conversion surgery.