RT Journal Article
SR Electronic
T1 <em>In Vitro</em> Assessment of the Antioxidant and Anticancer Properties of <em>Flammulina velutipes</em> Stipe Extracts
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3057
OP 3067
DO 10.21873/anticanres.16477
VO 43
IS 7
A1 CHEN, CHIEN-CHIN
A1 TANG, CHUNG-TAO
A1 LAI, CHAO-YANG
A1 HAN, CHIEN-KUO
A1 CHENG, YU-HSUAN
A1 LIN, YU-FENG
A1 LIN, CHENG-TING
A1 HUANG, YUAN-LI
YR 2023
UL http://ar.iiarjournals.org/content/43/7/3057.abstract
AB Background/Aim: Flammulina velutipes (FV), also known as the golden needle mushroom, is an edible and medicinal fungus that contains bioactive substances regulating various physiological functions. While the fruiting bodies of FV are commonly consumed, their stipes are often discarded despite containing polysaccharides. In this study, the biological functions of FV stipes (FV-S) were investigated to reduce waste and pollution while increasing their value. Materials and Methods: The antioxidant activity of FV was evaluated using three methods: the DPPH radical-scavenging capacity assay, ferrous ion chelating assay, and reducing power analysis. The anti-cancer potential was assessed through MTT viability and immunoblotting analyses. Results: Results showed that FV-S had higher polysaccharide and total phenolic contents and greater antioxidant abilities, particularly in ethanolic extracts. FV-S also exhibited significant anticancer properties, specifically in hot water extracts with high polysaccharide contents, and suppressed prostate cancer cell viability by inhibiting androgen receptor and PCa-specific antigen mRNA expression while inducing caspase-3/7 activation. Conclusion: FV-S is rich in bioactive components, possesses higher antioxidant and anticancer abilities, and has potential as an anticancer agent, which could enhance the value of FV.