TY - JOUR T1 - CD2 Promoter Regulated Nucleophosmin-anaplastic Lymphoma Kinase in Transgenic Mice Causes B Lymphoid Malignancy JF - Anticancer Research JO - Anticancer Res SP - 3275 LP - 3279 VL - 26 IS - 5A AU - SUZANNE D. TURNER AU - HARTMUT MERZ AU - DEBRA YEUNG AU - DENIS R. ALEXANDER Y1 - 2006/09/01 UR - http://ar.iiarjournals.org/content/26/5A/3275.abstract N2 - Background: Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. Materials and Methods: We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter. Results: Surprisingly, the mice develop B cell lymphomas in the majority of cases. Conclusion: These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -