RT Journal Article SR Electronic T1 Comparison of ID8 MOSE and VEGF-modified ID8 Cell Lines in an Immunocompetent Animal Model for Human Ovarian Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2785 OP 2789 VO 26 IS 4B A1 JANÁT-AMSBURY, MARGIT MARIA A1 YOCKMAN, JAMES WILLIAM A1 ANDERSON, MATTHEW LINLEY A1 KIEBACK, DIRK GÜNTER A1 KIM, SUNG WAN YR 2006 UL http://ar.iiarjournals.org/content/26/4B/2785.abstract AB Attempts to develop novel immunotherapeutic mouse models have been hampered by the lack of an adequate in vivo system. This study was performed to establish an immunocompetent mouse model for the testing of immunotherapy concepts. The in vivo system was based on a syngeneic mouse ovarian surface epithelium (MOSE) cancer, physiologically and biologically closely resembling human epithelial ovarian cancer. In addition, a more aggressive variant containing a mutated form of vascular epithelial growth factor was also evaluated. The growth patterns of these ovarian cancer cells in mice were compared to the established, highly aggressive 4T1 breast cancer model. A clinically-relevant tool for the study of different growth patterns in ovarian cancer, with potential significance for the development of novel immunological methods, was successfully developed. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved