PT - JOURNAL ARTICLE AU - JANÁT-AMSBURY, MARGIT MARIA AU - YOCKMAN, JAMES WILLIAM AU - ANDERSON, MATTHEW LINLEY AU - KIEBACK, DIRK GÜNTER AU - KIM, SUNG WAN TI - Comparison of ID8 MOSE and VEGF-modified ID8 Cell Lines in an Immunocompetent Animal Model for Human Ovarian Cancer DP - 2006 Jul 01 TA - Anticancer Research PG - 2785--2789 VI - 26 IP - 4B 4099 - http://ar.iiarjournals.org/content/26/4B/2785.short 4100 - http://ar.iiarjournals.org/content/26/4B/2785.full SO - Anticancer Res2006 Jul 01; 26 AB - Attempts to develop novel immunotherapeutic mouse models have been hampered by the lack of an adequate in vivo system. This study was performed to establish an immunocompetent mouse model for the testing of immunotherapy concepts. The in vivo system was based on a syngeneic mouse ovarian surface epithelium (MOSE) cancer, physiologically and biologically closely resembling human epithelial ovarian cancer. In addition, a more aggressive variant containing a mutated form of vascular epithelial growth factor was also evaluated. The growth patterns of these ovarian cancer cells in mice were compared to the established, highly aggressive 4T1 breast cancer model. A clinically-relevant tool for the study of different growth patterns in ovarian cancer, with potential significance for the development of novel immunological methods, was successfully developed. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved