RT Journal Article SR Electronic T1 Follow-up of High-grade Squamous Intra-epithelial Lesions (H-SILs) in Human Immunodeficiency Virus (HIV)-positive and Human Papillomavirus (HPV)-positive Women. Analysis of Risk Factors JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3167 OP 3170 VO 26 IS 4B A1 FREGA, ANTONIO A1 BIAMONTI, ALBERTO A1 MARANGHI, LUCA A1 VETRANO, GIUSEPPE A1 PALAZZO, ANTONELLA A1 IACOVELLI, ROBERTO A1 COROSU, ROBERTO A1 FRENCH, DEBORAH A1 MOSCARINI, MASSIMO A1 VECCHIONE, ALDO YR 2006 UL http://ar.iiarjournals.org/content/26/4B/3167.abstract AB Background: Human immunodeficiency virus (HIV)-positive women are at high risk of co-infection from human papillomavirus (HPV) and of developing squamous intra-epithelial lesions of the cervix. Materials and Methods: From April 1997 to March 1999, 86 women, affected by high-grade squamous intra-epithelial lesions (H-SILs), were enrolled: 41 were HIV+ (CD4+ count >500/ml) and 45 were HIV-. The diagnosis of high-grade squamous intra-epithelial lesion (H-SIL) was established for each patient by Pap test, colposcopy and guided biopsy. For all samples, the HPV/DNA test was also performed by PCR. The patients' lesions and recurrence were treated by cone biopsy or large loop excision (LEEP). Annual controls were performed for 5 years. Results: A high rate of alcohol and drug use (60.7% vs. 31.4%; p=0.004; 80% vs. 27.5%; p<0.001, respectively) and number of male partners (4.5 vs. 3.0; p<0.001) were found in the HIV+ patients, compared to the HIV- patients. Both groups were HPV+ for high-risk types. No difference was found in the percentage of patients who had received a second LEEP. Conclusion: Our findings suggest the treatment of H-SIL in HIV-positive women, for a longer disease-free survival, or a lower risk of developing cervical cancer. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved