PT - JOURNAL ARTICLE AU - FREGA, ANTONIO AU - BIAMONTI, ALBERTO AU - MARANGHI, LUCA AU - VETRANO, GIUSEPPE AU - PALAZZO, ANTONELLA AU - IACOVELLI, ROBERTO AU - COROSU, ROBERTO AU - FRENCH, DEBORAH AU - MOSCARINI, MASSIMO AU - VECCHIONE, ALDO TI - Follow-up of High-grade Squamous Intra-epithelial Lesions (H-SILs) in Human Immunodeficiency Virus (HIV)-positive and Human Papillomavirus (HPV)-positive Women. Analysis of Risk Factors DP - 2006 Jul 01 TA - Anticancer Research PG - 3167--3170 VI - 26 IP - 4B 4099 - http://ar.iiarjournals.org/content/26/4B/3167.short 4100 - http://ar.iiarjournals.org/content/26/4B/3167.full SO - Anticancer Res2006 Jul 01; 26 AB - Background: Human immunodeficiency virus (HIV)-positive women are at high risk of co-infection from human papillomavirus (HPV) and of developing squamous intra-epithelial lesions of the cervix. Materials and Methods: From April 1997 to March 1999, 86 women, affected by high-grade squamous intra-epithelial lesions (H-SILs), were enrolled: 41 were HIV+ (CD4+ count >500/ml) and 45 were HIV-. The diagnosis of high-grade squamous intra-epithelial lesion (H-SIL) was established for each patient by Pap test, colposcopy and guided biopsy. For all samples, the HPV/DNA test was also performed by PCR. The patients' lesions and recurrence were treated by cone biopsy or large loop excision (LEEP). Annual controls were performed for 5 years. Results: A high rate of alcohol and drug use (60.7% vs. 31.4%; p=0.004; 80% vs. 27.5%; p<0.001, respectively) and number of male partners (4.5 vs. 3.0; p<0.001) were found in the HIV+ patients, compared to the HIV- patients. Both groups were HPV+ for high-risk types. No difference was found in the percentage of patients who had received a second LEEP. Conclusion: Our findings suggest the treatment of H-SIL in HIV-positive women, for a longer disease-free survival, or a lower risk of developing cervical cancer. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved