RT Journal Article
SR Electronic
T1 Antiproliferative Activity of Vitamin D Compounds in Combination with Cytostatics
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2701
OP 2705
VO 26
IS 4A
A1 PELCZYNSKA, MARZENA
A1 SWITALSKA, MARTA
A1 MACIEJEWSKA, MAGDALENA
A1 JAROSZEWICZ, IWONA
A1 KUTNER, ANDRZEJ
A1 OPOLSKI, ADAM
YR 2006
UL http://ar.iiarjournals.org/content/26/4A/2701.abstract
AB Calcitriol is a potent antiproliferative agent against various tumour cells in vitro. Here, the results of a study on vitamin D compounds (calcitriol's analogues PRI-1906 and PRI-2191) as potential agents in combined antitumour therapy in vitro are presented. Applying antiproliferative SRB and MTT assays, the growth inhibitory effects of the vitamin D compounds, applied alone or in combination with either cisplatin or doxorubicin, were measured. The following cancer cell lines were employed: A549 (human non-small cell lung carcinoma), B16 (murine melanoma), CCRF, HL-60 (human leukaemia), SW707 (human colon cancer), MCF-7, T47D (human breast cancer), WEHI-3 (mouse leukaemia) and normal cells: BALB 3T3 (normal murine fibroblast cell line). It was shown that the treatment of tumour cells, which are sensitive to vitamin D compounds, with the combination of vitamin D compounds and cytostatics decreased the inhibitory concentration 50% (IC50) values compared with the effects of the cytostatics applied alone. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved