PT  - JOURNAL ARTICLE
AU  - CELIK, EREN
AU  - BAUES, CHRISTIAN
AU  - TROMMER, MAIKE
AU  - FAN, JIAQI
AU  - NADJIRI, LUKAS
AU  - ROSENBROCK, JOHANNES
AU  - LINDE, PHILIPP
TI  - Dose-dependent Effects of Unintended Splenic Irradiation After Neoadjuvant Radiochemotherapy for Esophageal Cancer
AID  - 10.21873/anticanres.16440
DP  - 2023 Jun 01
TA  - Anticancer Research
PG  - 2733--2739
VI  - 43
IP  - 6
4099  - http://ar.iiarjournals.org/content/43/6/2733.short
4100  - http://ar.iiarjournals.org/content/43/6/2733.full
SO  - Anticancer Res2023 Jun 01; 43
AB  - Background/Aim: The aim of this study was to investigate the relationship between radiation exposure to the spleen, dose-dependent organ changes, and their possible influence on clinical and oncological outcome. Furthermore, to provide evidence and sensitivity for considering the spleen as an relevant organ at risk. Patients and Methods: A total of 93 patients with carcinoma of the distal esophagus or gastroesophageal junction were selected for this retrospective study. Changes in spleen volume, infections, and oncological outcome were assessed during follow-up using linear and logistic regression models. Results: Spleen volume decreased significantly by a median of 27.5 ml to an absolute value of 178.1 ml (p<0.001) within twelve months. Statistical analyses revealed a significant association of infectious events with worse progression-free survival (PFS) (p=0.002) and overall survival (OS) (p=0.001). With a mean spleen dose <4 Gray, both OS and PFS were also significantly prolonged. Conclusion: A decrease in spleen organ volume after neoadjuvant radiochemotherapy was demonstrated with a consecutive increased incidence of infectious events, significantly correlating with worse PFS and OS.