RT Journal Article SR Electronic T1 A Direct Mechanistic Link between Growth Control and a Tumor Cell Immune Function: Increased Interleukin-8 Secretion Accounts for Elimination of Oct-1 Antisense Transformants from Scid Mice JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1733 OP 1738 VO 26 IS 3A A1 PALUBIN, KIMBERLY M. A1 GOODWIN, BONNIE L. A1 NIESEN, MELISSA I. A1 LE, ELIZABETH A. A1 OSBORNE, AARON R. A1 BLANCK, GEORGE YR 2006 UL http://ar.iiarjournals.org/content/26/3A/1733.abstract AB Background: Tumorigenesis involves the aberrant function of proteins that regulate growth control, including Oct-1. Oct-1 is a DNA binding transcription factor that activates genes that encode proteins required for S-phase and cell growth. For example, Oct-1 activates the histone H2B promoter and the promoters for the snRNPs. Oct-1 also represses certain promoters, including promoters of immune function genes, such as the IL-8 and the HLA-DRA genes. Materials, Methods and Results: Oct-1 antisense transformants were determined to have reduced growth rates and other characteristics of growth control. Also, Oct-1 antisense transformants endured for a shorter time in scid mice, being attributable to the increased expression of IL-8 by the Oct-1 antisense transformants. Conclusion: These results may help resolve the conundrum of why growth control de-regulation alone is not enough for tumorigenicity. The results also support the conclusion that the molecular mechanisms of growth control de-regulation and tumor cell immune functions are directly linked.