<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">PALUBIN, KIMBERLY M.</style></author><author><style face="normal" font="default" size="100%">GOODWIN, BONNIE L.</style></author><author><style face="normal" font="default" size="100%">NIESEN, MELISSA I.</style></author><author><style face="normal" font="default" size="100%">LE, ELIZABETH A.</style></author><author><style face="normal" font="default" size="100%">OSBORNE, AARON R.</style></author><author><style face="normal" font="default" size="100%">BLANCK, GEORGE</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">A Direct Mechanistic Link between Growth Control and a Tumor Cell Immune Function: Increased Interleukin-8 Secretion Accounts for Elimination of Oct-1 Antisense Transformants from &lt;em&gt;Scid&lt;/em&gt; Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-05-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1733-1738</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">3A</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Tumorigenesis involves the aberrant function of proteins that regulate growth control, including Oct-1. Oct-1 is a DNA binding transcription factor that activates genes that encode proteins required for S-phase and cell growth. For example, Oct-1 activates the histone H2B promoter and the promoters for the snRNPs. Oct-1 also represses certain promoters, including promoters of immune function genes, such as the IL-8 and the HLA-DRA genes. Materials, Methods and Results: Oct-1 antisense transformants were determined to have reduced growth rates and other characteristics of growth control. Also, Oct-1 antisense transformants endured for a shorter time in scid mice, being attributable to the increased expression of IL-8 by the Oct-1 antisense transformants. Conclusion: These results may help resolve the conundrum of why growth control de-regulation alone is not enough for tumorigenicity. The results also support the conclusion that the molecular mechanisms of growth control de-regulation and tumor cell immune functions are directly linked.</style></abstract></record></records></xml>