RT Journal Article
SR Electronic
T1 Expression of IL-10 in Patients with Ovarian Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1715
OP 1718
VO 26
IS 2C
A1 MUSTEA, ALEXANDER
A1 KÖNSGEN, DOMINIQUE
A1 BRAICU, ELENA IOANA
A1 PIRVULESCU, CRISTINA
A1 SUN, PENGMING
A1 SOFRONI, DUMITRU
A1 LICHTENEGGER, WERNER
A1 SEHOULI, JALID
YR 2006
UL http://ar.iiarjournals.org/content/26/2C/1715.abstract
AB Background: Cytokines are involved in the pathogenesis of different gynecological malignancies. Additionally, they stimulate the spread of cancer cells. Interleukin 10 (IL-10) was described as a pro-inflammatory factor and seems to be implicated in the immune deficiency of patients with cancer. The aim of this study was to determine whether the level of IL-10 in the serum and ascites was associated with the prognosis of advanced ovarian cancer (OC). Materials and Methods: In a prospective study from 2001 to 2003, the concentration of IL-10 in the serum and ascites of 117 consecutive patients with advanced OC and 30 women with benign disease who underwent surgery as a control group (CG), was analyzed by the enzyme-linked immunosorbent assay. For statistical analyses, the Chi-square test by Pearson, Fisher's exact test and the Mann-Whitney test were employed. Results: The concentrations of IL-10 were a median of 9.87 pg/ml (range 7.8 to 500 pg/ml) in the serum and a median of 43.70 pg/ml (range 7.8 to 389.4 pg/ml) in the ascites of the OC patients. The IL-10 level in the sera of the CG was a median of 7.80 pg/ml (range 7.8 to 62.8 pg/ml) and 18.34 pg/ml (range 7.8 to 88.72 pg/ml) in the peritoneal fluid. A significant association was observed between the IL-10 serum levels (p=0.003) and levels in the peritoneal fluid (p=0.03) in both OC and the CG. IL-10 was significantly more expressed in the ascites of patients with OC than in their sera (p=0.003). The concentration of IL-10 correlated significantly with proven conventional prognostic factors such as recurrence status (p=0.005), volume of (ascites, p<0.001, serum, p=0.03), histological grading (p=0.053) and histological type (ascites p=0.005/ serum p=0.09). There was no significant correlation between the levels of IL-10 in the ascites and/or serum and FIGO stage, residual tumor mass or age. The cut-off value of 8.0 pg/ml for IL-10 serum levels had a positive predictive value of 84% (95% CI: 76-91) and a negative predictive value of 29% (95% CI: 16-41), with a specificity and sensibility of 47% (95% CI: 29-65) and 70% (95% CI: 62-78), respectively. Conclusion: Due to the fact that the levels of IL-10 were significantly higher in the ascites and serum of OC patients than in those of the CG, IL-10 may play an important immunosuppressive role in the pathogenesis of OC. The association between high IL-10 levels in ascites and serum and the histological type of the tumor, as well as between the levels in the peritoneal cavity and grading, suggest that IL-10 could be a prognostic factor in OC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved