<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MUSTEA, ALEXANDER</style></author><author><style face="normal" font="default" size="100%">KÖNSGEN, DOMINIQUE</style></author><author><style face="normal" font="default" size="100%">BRAICU, ELENA IOANA</style></author><author><style face="normal" font="default" size="100%">PIRVULESCU, CRISTINA</style></author><author><style face="normal" font="default" size="100%">SUN, PENGMING</style></author><author><style face="normal" font="default" size="100%">SOFRONI, DUMITRU</style></author><author><style face="normal" font="default" size="100%">LICHTENEGGER, WERNER</style></author><author><style face="normal" font="default" size="100%">SEHOULI, JALID</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of IL-10 in Patients with Ovarian Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1715-1718</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">2C</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Cytokines are involved in the pathogenesis of different gynecological malignancies. Additionally, they stimulate the spread of cancer cells. Interleukin 10 (IL-10) was described as a pro-inflammatory factor and seems to be implicated in the immune deficiency of patients with cancer. The aim of this study was to determine whether the level of IL-10 in the serum and ascites was associated with the prognosis of advanced ovarian cancer (OC). Materials and Methods: In a prospective study from 2001 to 2003, the concentration of IL-10 in the serum and ascites of 117 consecutive patients with advanced OC and 30 women with benign disease who underwent surgery as a control group (CG), was analyzed by the enzyme-linked immunosorbent assay. For statistical analyses, the Chi-square test by Pearson, Fisher's exact test and the Mann-Whitney test were employed. Results: The concentrations of IL-10 were a median of 9.87 pg/ml (range 7.8 to 500 pg/ml) in the serum and a median of 43.70 pg/ml (range 7.8 to 389.4 pg/ml) in the ascites of the OC patients. The IL-10 level in the sera of the CG was a median of 7.80 pg/ml (range 7.8 to 62.8 pg/ml) and 18.34 pg/ml (range 7.8 to 88.72 pg/ml) in the peritoneal fluid. A significant association was observed between the IL-10 serum levels (p=0.003) and levels in the peritoneal fluid (p=0.03) in both OC and the CG. IL-10 was significantly more expressed in the ascites of patients with OC than in their sera (p=0.003). The concentration of IL-10 correlated significantly with proven conventional prognostic factors such as recurrence status (p=0.005), volume of (ascites, p&lt;0.001, serum, p=0.03), histological grading (p=0.053) and histological type (ascites p=0.005/ serum p=0.09). There was no significant correlation between the levels of IL-10 in the ascites and/or serum and FIGO stage, residual tumor mass or age. The cut-off value of 8.0 pg/ml for IL-10 serum levels had a positive predictive value of 84% (95% CI: 76-91) and a negative predictive value of 29% (95% CI: 16-41), with a specificity and sensibility of 47% (95% CI: 29-65) and 70% (95% CI: 62-78), respectively. Conclusion: Due to the fact that the levels of IL-10 were significantly higher in the ascites and serum of OC patients than in those of the CG, IL-10 may play an important immunosuppressive role in the pathogenesis of OC. The association between high IL-10 levels in ascites and serum and the histological type of the tumor, as well as between the levels in the peritoneal cavity and grading, suggest that IL-10 could be a prognostic factor in OC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>