RT Journal Article
SR Electronic
T1 Overexpression of the Plasminogen Activator Inhibitor Type-1 in Epithelial Ovarian Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1683
OP 1689
VO 26
IS 2C
A1 KOENSGEN, D.
A1 MUSTEA, A.
A1 DENKERT, C.
A1 SUN, P.M.
A1 LICHTENEGGER, W.
A1 SEHOULI, J.
YR 2006
UL http://ar.iiarjournals.org/content/26/2C/1683.abstract
AB Background: The plasminogen activator-plasmin cascade plays a central role in the progression of solid tumors. The type-1 plasminogen activator inhibitor (PAI-1) is the major physiological regulator of plasminogen activation. PAI-1 is suggested to play a crucial role in tumor cell invasion and metastasis of various solid tumors. The aim of this study was to analyze the clinical and prognostic roles of PAI-1 in epithelial ovarian cancer (OC). Materials and Methods: Expression analysis was conducted by immunohistochemistry and ELISA. Tissue sections of paraffin-embedded tumor specimens and fresh-frozen tumor samples from patients with benign and malignant ovarian tumors (OT), who had undergone surgical intervention in the Department of Gynaecology and Obstetrics, Charité, Germany, from 02/01 to 06/02, were used. Correlation analysis with conventional clinical factors, univariate and multivariate analyses were performed using SPSS (SPSS Inc., V.11.0). Results: Sixty-five patients (31 primary OC, 20 recurrent OC, 4 low-malignant potential OT, 6 benign OT, 4 normal ovary) were allocated to this trial. The median age was 57 years (range, 34-86) and the median follow-up was 20 months (range, 0-64). The distributions of (FIGO) tumor stage of all primary OC were: I=16.1%, II=3.2%, III=45.2% and IV=35.5%. PAI-1 was significantly overexpressed in the tumor epithelium of OC in comparison to the ovarian epithelium of benign OT and normal ovary (p<0.001). The median PAI-1 level was 1.92-fold higher in malignant OT than in benign OT. Statistical analyses showed no significant correlation between the expression of PAI-1 and clinical parameters. The expression of PAI-1 and the PAI-1 level, according to 3 different cut-off values, showed no prognostic impact in univariate analysis. In multivariate analysis, only tumor stage (FIGO) (p=0.003) and residual tumor (p=0.009) remained independent prognostic factors for post-operative survival. Conclusion: PAI-1 is significantly overexpressed in OC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved