RT Journal Article
SR Electronic
T1 Options and Limits of Surgery after Pre-operative Chemotherapy in Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1677
OP 1682
VO 26
IS 2C
A1 THOMAS, ANKE
A1 OHLINGER, RALF
A1 HAUSCHILD, MAIK
A1 MUSTEA, ALEXANDER
A1 BLOHMER, JENS-UWE
A1 KÜMMEL, SHERKO
YR 2006
UL http://ar.iiarjournals.org/content/26/2C/1677.abstract
AB The primary administration of chemotherapy leads to a reduction in size of tumors, increasing the possibility of breast-conserving surgery in both locally advanced, inoperable and primary operable mamma carcinomas. This, however, increases the rate of local relapse and the rate of mastectomy over the course of the disease, even although the EUSOMA guidelines are not exceeded. Whether the pre-surgical administration of chemotherapy with pathological complete remission actually increases the disease-free rate and overall survival remains to be determined. Further clinical studies are required to establish the reliability of sentinel lymph-node biopsy; currently, axillary lymphadenectomy is still the standard therapy. The response of the tumor to therapy, in correlation with predictive factors and the molecular-genetic profile, could make more individualized treatment regimes possible in the future. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved