RT Journal Article
SR Electronic
T1 Expression of p27<sup>KIP1</sup>, p21<sup>WAF1</sup> and p53 does Not Correlate with Prognosis in Node-negative Invasive Ductal Carcinoma of the Breast
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1657
OP 1668
VO 26
IS 2B
A1 KOUREA, HELEN P.
A1 KOUTRAS, ANGELOS K.
A1 ZOLOTA, VASSILIKI
A1 GRIMANI, IRENE
A1 TZORACOELEFTHERAKIS, EVANGELOS
A1 KOUKOURAS, DIMITRIOS
A1 FOUNTZILAS, GEORGE
A1 GOGAS, HELEN
A1 KYRIAKOU, KYRIAKOS
A1 ADAMOU, ADAMOS
A1 KALOFONOS, HARALAMBOS P.
YR 2006
UL http://ar.iiarjournals.org/content/26/2B/1657.abstract
AB The expressions of p27Kip1 (p27) and p21Waf1 (p21) cyclin-dependent kinase inhibitors and p53 were examined in a series of 170 node-negative breast carcinomas (NNBCs) to evaluate their prognostic significance. Low nuclear (p27TN) and cytoplasmic (p27TC) p27 expressions were noted in 66% and 81% of NNBCs, respectively. p21 and p53 overexpressions were detected in 56% and 26%, respectively. Low p27TN was significantly associated with high grade (p=0.001), age ≤50 years (p=0.01), negative hormone receptors (p&lt;0.001), low p27TC (p&lt;0.001) and p53 overexpression (p=0.02). Low p27TC was associated with negative hormone receptors (p&lt;0.001). p53 overexpression was associated with high grade (p&lt;0.001) and negative hormone receptors (p&lt;0.001). p21 overexpression, although not correlated with the examined parameters, was associated with increased disease-free survival in univariate analysis. In multivariate analysis, p27TN, p27TC, p21 and p53 were not associated with disease-free survival or overall survival. These findings argue against the prognostic value of p27, p21 and p53 in NNBC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved