PT  - JOURNAL ARTICLE
AU  - KOUREA, HELEN P.
AU  - KOUTRAS, ANGELOS K.
AU  - ZOLOTA, VASSILIKI
AU  - GRIMANI, IRENE
AU  - TZORACOELEFTHERAKIS, EVANGELOS
AU  - KOUKOURAS, DIMITRIOS
AU  - FOUNTZILAS, GEORGE
AU  - GOGAS, HELEN
AU  - KYRIAKOU, KYRIAKOS
AU  - ADAMOU, ADAMOS
AU  - KALOFONOS, HARALAMBOS P.
TI  - Expression of p27<sup>KIP1</sup>, p21<sup>WAF1</sup> and p53 does Not Correlate with Prognosis in Node-negative Invasive Ductal Carcinoma of the Breast
DP  - 2006 Mar 01
TA  - Anticancer Research
PG  - 1657--1668
VI  - 26
IP  - 2B
4099  - http://ar.iiarjournals.org/content/26/2B/1657.short
4100  - http://ar.iiarjournals.org/content/26/2B/1657.full
SO  - Anticancer Res2006 Mar 01; 26
AB  - The expressions of p27Kip1 (p27) and p21Waf1 (p21) cyclin-dependent kinase inhibitors and p53 were examined in a series of 170 node-negative breast carcinomas (NNBCs) to evaluate their prognostic significance. Low nuclear (p27TN) and cytoplasmic (p27TC) p27 expressions were noted in 66% and 81% of NNBCs, respectively. p21 and p53 overexpressions were detected in 56% and 26%, respectively. Low p27TN was significantly associated with high grade (p=0.001), age ≤50 years (p=0.01), negative hormone receptors (p<0.001), low p27TC (p<0.001) and p53 overexpression (p=0.02). Low p27TC was associated with negative hormone receptors (p<0.001). p53 overexpression was associated with high grade (p<0.001) and negative hormone receptors (p<0.001). p21 overexpression, although not correlated with the examined parameters, was associated with increased disease-free survival in univariate analysis. In multivariate analysis, p27TN, p27TC, p21 and p53 were not associated with disease-free survival or overall survival. These findings argue against the prognostic value of p27, p21 and p53 in NNBC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved