<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">KOUREA, HELEN P.</style></author><author><style face="normal" font="default" size="100%">KOUTRAS, ANGELOS K.</style></author><author><style face="normal" font="default" size="100%">ZOLOTA, VASSILIKI</style></author><author><style face="normal" font="default" size="100%">GRIMANI, IRENE</style></author><author><style face="normal" font="default" size="100%">TZORACOELEFTHERAKIS, EVANGELOS</style></author><author><style face="normal" font="default" size="100%">KOUKOURAS, DIMITRIOS</style></author><author><style face="normal" font="default" size="100%">FOUNTZILAS, GEORGE</style></author><author><style face="normal" font="default" size="100%">GOGAS, HELEN</style></author><author><style face="normal" font="default" size="100%">KYRIAKOU, KYRIAKOS</style></author><author><style face="normal" font="default" size="100%">ADAMOU, ADAMOS</style></author><author><style face="normal" font="default" size="100%">KALOFONOS, HARALAMBOS P.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of p27&lt;sup&gt;KIP1&lt;/sup&gt;, p21&lt;sup&gt;WAF1&lt;/sup&gt; and p53 does Not Correlate with Prognosis in Node-negative Invasive Ductal Carcinoma of the Breast</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">1657-1668</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">2B</style></issue><abstract><style  face="normal" font="default" size="100%">The expressions of p27Kip1 (p27) and p21Waf1 (p21) cyclin-dependent kinase inhibitors and p53 were examined in a series of 170 node-negative breast carcinomas (NNBCs) to evaluate their prognostic significance. Low nuclear (p27TN) and cytoplasmic (p27TC) p27 expressions were noted in 66% and 81% of NNBCs, respectively. p21 and p53 overexpressions were detected in 56% and 26%, respectively. Low p27TN was significantly associated with high grade (p=0.001), age ≤50 years (p=0.01), negative hormone receptors (p&lt;0.001), low p27TC (p&lt;0.001) and p53 overexpression (p=0.02). Low p27TC was associated with negative hormone receptors (p&lt;0.001). p53 overexpression was associated with high grade (p&lt;0.001) and negative hormone receptors (p&lt;0.001). p21 overexpression, although not correlated with the examined parameters, was associated with increased disease-free survival in univariate analysis. In multivariate analysis, p27TN, p27TC, p21 and p53 were not associated with disease-free survival or overall survival. These findings argue against the prognostic value of p27, p21 and p53 in NNBC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>