RT Journal Article
SR Electronic
T1 Laparoscopic Liver Resection Procedure Attenuates Organ-space Surgical Site Infection Compared With Open Procedure: A Propensity Score-matched Analysis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2273
OP 2280
DO 10.21873/anticanres.16391
VO 43
IS 5
A1 ARAKI, KENICHIRO
A1 HARIMOTO, NORIFUMI
A1 WATANABE, AKIRA
A1 TSUKAGOSHI, MARIKO
A1 ISHII, NORIHIRO
A1 HAGIWARA, KEI
A1 MURANUSHI, RYO
A1 HOSHINO, KOUKI
A1 SEKI, TAKAOMI
A1 SHIRABE, KEN
YR 2023
UL http://ar.iiarjournals.org/content/43/5/2273.abstract
AB Background/Aim: Theoretically, laparoscopic procedures reduce the incidence of surgical site infection (SSI) compared with open surgery. This study aimed to investigate whether laparoscopic liver resection (LLR) attenuates organ-space SSI compared with open liver resection (OLR) using propensity score-matched (PSM) analysis. Patients and Methods: This study included 530 patients who underwent liver resection as the original cohort. PSM was conducted to adjust for confounding factors between OLR and LLR. Two groups were compared regarding the incidence of postoperative complications, including organ-space SSI. We also evaluated risk factors for organ-space SSI using univariate and multivariate analyses. Results: In the original cohort, incidence of bile leakage (p<0.001) and organ-space SSI (p<0.001) were significantly lower in the LLR group than those in the OLR group. A pair of 105 patients were selected for the PSM analysis. After matching, LLR was significantly associated with lower blood loss (p<0.001), longer Pringle clamp time (p<0.001), lower incidence of bile leakage (p=0.035), organ-space SSI (p=0.035), Clavien–Dindo grade ≥III complications (p=0.005), and longer length of hospital stay (p<0.001) than OLR. In multivariate analysis, OLR (p=0.045) was an independent risk factor for organ-space SSI. Conclusion: LLR has potential to reduce the risk of organ-space SSI caused by intra-abdominal abscess and bile leakage more than OLR.