PT - JOURNAL ARTICLE AU - KENICHIRO ARAKI AU - NORIFUMI HARIMOTO AU - AKIRA WATANABE AU - MARIKO TSUKAGOSHI AU - NORIHIRO ISHII AU - KEI HAGIWARA AU - RYO MURANUSHI AU - KOUKI HOSHINO AU - TAKAOMI SEKI AU - KEN SHIRABE TI - Laparoscopic Liver Resection Procedure Attenuates Organ-space Surgical Site Infection Compared With Open Procedure: A Propensity Score-matched Analysis AID - 10.21873/anticanres.16391 DP - 2023 May 01 TA - Anticancer Research PG - 2273--2280 VI - 43 IP - 5 4099 - http://ar.iiarjournals.org/content/43/5/2273.short 4100 - http://ar.iiarjournals.org/content/43/5/2273.full SO - Anticancer Res2023 May 01; 43 AB - Background/Aim: Theoretically, laparoscopic procedures reduce the incidence of surgical site infection (SSI) compared with open surgery. This study aimed to investigate whether laparoscopic liver resection (LLR) attenuates organ-space SSI compared with open liver resection (OLR) using propensity score-matched (PSM) analysis. Patients and Methods: This study included 530 patients who underwent liver resection as the original cohort. PSM was conducted to adjust for confounding factors between OLR and LLR. Two groups were compared regarding the incidence of postoperative complications, including organ-space SSI. We also evaluated risk factors for organ-space SSI using univariate and multivariate analyses. Results: In the original cohort, incidence of bile leakage (p<0.001) and organ-space SSI (p<0.001) were significantly lower in the LLR group than those in the OLR group. A pair of 105 patients were selected for the PSM analysis. After matching, LLR was significantly associated with lower blood loss (p<0.001), longer Pringle clamp time (p<0.001), lower incidence of bile leakage (p=0.035), organ-space SSI (p=0.035), Clavien–Dindo grade ≥III complications (p=0.005), and longer length of hospital stay (p<0.001) than OLR. In multivariate analysis, OLR (p=0.045) was an independent risk factor for organ-space SSI. Conclusion: LLR has potential to reduce the risk of organ-space SSI caused by intra-abdominal abscess and bile leakage more than OLR.