RT Journal Article
SR Electronic
T1 Effectiveness of Spacers in Brachytherapy With <sup>198</sup>Au Grains for Patients With Buccal Mucosa Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2265
OP 2271
DO 10.21873/anticanres.16390
VO 43
IS 5
A1 KONISHI, MASARU
A1 HIROKAWA, JUNICHI
A1 MIYOSHI, SHOTA
A1 KATSUTA, TSUYOSHI
A1 IMANO, NOBUKI
A1 NISHIBUCHI, IKUNO
A1 MURAKAMI, YUJI
A1 SHIMABUKURO, KIICHI
A1 NAKASHIMA, TAKEO
A1 TAKEUCHI, YUKI
A1 KAKIMOTO, NAOYA
A1 NAGATA, YASUSHI
YR 2023
UL http://ar.iiarjournals.org/content/43/5/2265.abstract
AB Background/Aim: The aim of this study was to investigate the use of spacers and their efficacy in brachytherapy with 198Au grains for buccal mucosa cancer. Patients and Methods: Sixteen patients with squamous cell carcinoma of the buccal mucosa who were treated with 198Au grain brachytherapy were included. The distance between 198Au grains, distance between 198Au grains and the maxilla or mandible, and the maximum dose/cc to the jawbone (D1cc) with and without a spacer was investigated in three out of 16 patients. Results: The median distance between 198Au grains without and with a spacer was 7.4 and 10.7 mm, respectively; this was significantly different. The median distance between 198Au grains and the maxilla without and with a spacer was 10.3 and 18.5 mm, respectively; again this was significantly different. The median distance between 198Au grains and the mandible without and with a spacer was 8.6 and 17.3 mm, respectively; the difference was significant. The D1cc to the maxilla without and with a spacer were 14.9, 68.7, and 51.8 Gy and 7.5, 21.2, and 40.7 Gy in cases 1, 2, and 3, respectively. The D1cc to the mandible without and with a spacer were 27.5, 68.7, and 85.8 Gy and 11.3, 53.6, and 64.9 Gy in cases 1, 2, and 3, respectively. No osteoradionecrosis of the jaw bones was observed in any case. Conclusion: The spacer enabled maintenance of the distance between 198Au grains, and between 198Au grains and the jawbone. In buccal mucosa cancer, using a spacer in brachytherapy with 198Au grains appears to reduce jawbone complications.