RT Journal Article
SR Electronic
T1 Genomic Instability and Cytotoxicity in Buccal Mucosal Cells of Workers in Banana Farming Evaluated by Micronucleus Test
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1283
OP 1286
DO 10.21873/anticanres.13239
VO 39
IS 3
A1 CLAUDIO, SAMUEL RANGEL
A1 SIMAS, JOSE MARTIM MARQUES
A1 SOUZA, ANA CAROLINA FLYGARE
A1 DO CARMO BARACHO DE ALENCAR, MARIA
A1 YAMAUCHI, LIRIA YURI
A1 RIBEIRO, DANIEL ARAKI
YR 2019
UL http://ar.iiarjournals.org/content/39/3/1283.abstract
AB Background/Aim: Studies have demonstrated the biological consequences of environmental contamination caused by human pesticide exposure following banana production. The aim of this study was to evaluate genomic instability and cytotoxicity in buccal mucosal cells of workers in banana farming. Materials and Methods: For this purpose, a total of 21 male workers in banana farming in the Ribeira Valley were included in the experimental group. A total of 20 individuals, not occupationally exposed to pesticides, were included in the control group. Results: The frequency of micronuclei was significantly increased (p<0.05) in buccal mucosa cells from workers of banana farming when compared to the control group. Furthermore, a high frequency of karyolysis was detected in buccal mucosaI cells in these individuals. No significant differences were found in pyknosis or karryorhexis when compared to controls. Conclusion: Taken together, our results indicate that workers in banana farming represent a group in high risk for carcinogenesis since chromosomal damage and cellular death are increased in these individuals.