PT  - JOURNAL ARTICLE
AU  - CLAUDIO, SAMUEL RANGEL
AU  - SIMAS, JOSE MARTIM MARQUES
AU  - SOUZA, ANA CAROLINA FLYGARE
AU  - DO CARMO BARACHO DE ALENCAR, MARIA
AU  - YAMAUCHI, LIRIA YURI
AU  - RIBEIRO, DANIEL ARAKI
TI  - Genomic Instability and Cytotoxicity in Buccal Mucosal Cells of Workers in Banana Farming Evaluated by Micronucleus Test
AID  - 10.21873/anticanres.13239
DP  - 2019 Mar 01
TA  - Anticancer Research
PG  - 1283--1286
VI  - 39
IP  - 3
4099  - http://ar.iiarjournals.org/content/39/3/1283.short
4100  - http://ar.iiarjournals.org/content/39/3/1283.full
SO  - Anticancer Res2019 Mar 01; 39
AB  - Background/Aim: Studies have demonstrated the biological consequences of environmental contamination caused by human pesticide exposure following banana production. The aim of this study was to evaluate genomic instability and cytotoxicity in buccal mucosal cells of workers in banana farming. Materials and Methods: For this purpose, a total of 21 male workers in banana farming in the Ribeira Valley were included in the experimental group. A total of 20 individuals, not occupationally exposed to pesticides, were included in the control group. Results: The frequency of micronuclei was significantly increased (p<0.05) in buccal mucosa cells from workers of banana farming when compared to the control group. Furthermore, a high frequency of karyolysis was detected in buccal mucosaI cells in these individuals. No significant differences were found in pyknosis or karryorhexis when compared to controls. Conclusion: Taken together, our results indicate that workers in banana farming represent a group in high risk for carcinogenesis since chromosomal damage and cellular death are increased in these individuals.