RT Journal Article
SR Electronic
T1 Reduced Galectin-3 Expression is an Indicator of Unfavorable Prognosis in Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1369
OP 1376
VO 26
IS 2B
A1 OKADA, KOHJI
A1 SHIMURA, TATSUO
A1 SUEHIRO, TAKETOSHI
A1 MOCHIKI, ERITO
A1 KUWANO, HIROYUKI
YR 2006
UL http://ar.iiarjournals.org/content/26/2B/1369.abstract
AB Background: Galectin-3 (gal-3) participates in a variety of biological events, including cell adhesion, proliferation, differentiation and apoptosis. The aim of this study was to determine the relationship of gal-3 expression with clinicopathological findings and prognosis in patients with gastric cancer. Patients and Methods: Gal-3 and Ki-67 expressions were assessed by immunohistochemistry in 115 patients with gastric cancer. PCR-single strand conformation polymorphism (SSCP)-sequence analysis and the levels of gal-3 mRNA were also examined. Results: The present study demonstrated that gal-3 expression was correlated with nodal status, lymphatic invasion, pathological stage and histological parameters. On the other hand, gal-3 expression did not correlate with the expression of Ki-67. Reduced expression of gal-3 was significantly associated with a poor prognosis and multivariate analysis showed that gal-3 expression was an independent prognostic factor. On PCR-SSCP-sequence analysis, 2 single nucleotide polymorphisms (SNPs) were detected in the gal-3 gene, but none showed mutations. Conclusion: Reduced gal-3 expression was associated with lymph node metastasis, advanced stage and tumor differentiation in gastric cancer. Gal-3 expression could be a useful prognostic factor in gastric cancer. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved