RT Journal Article SR Electronic T1 Surgical Treatments for Ductal Carcinoma In Situ (DCIS) in Elderly Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1555 OP 1562 DO 10.21873/anticanres.16305 VO 43 IS 4 A1 ORESTE CLAUDIO BUONOMO A1 MARCO PELLICCIARO A1 MARCO MATERAZZO A1 SIMONE BERARDI A1 PAOLA ELDA GIGLIOTTI A1 JONATHAN CASPI A1 ROSARIA MEUCCI A1 TOMMASO PERRETTA A1 ILARIA PORTARENA A1 MARIO DAURI A1 CHIARA ADRIANA PISTOLESE A1 GIANLUCA VANNI YR 2023 UL http://ar.iiarjournals.org/content/43/4/1555.abstract AB Background/Aim: Despite an aging population, there is no consensus regarding ductal carcinoma in situ (DCIS) treatment for elderly women. Breast surgery can be well tolerated even in elderly patients. The aim of this study is to evaluate the surgical management of DCIS in elderly patients. Patients and Methods: We retrospectively analyzed patients with DCIS from 2016 to 2022 at our Breast Unit and divided our population according to age. Results: Out of 231 patients with DCIS, 45 (19.5%) were elderly. The Charlson comorbidity index and American Society of Anesthesiology (ASA) score was significantly higher in the elderly (p<0.001 for both). Among the elderly, 10 (22.2%) patients received upstaging diagnoses, versus 18 (9.7%) in the control (p=0.048). Twelve (26.7%) of the elderly patients underwent sentinel lymph node biopsy, versus 93 (50%) in the control group (p=0.005). No difference was reported between groups in terms of breast conserving surgeries performed. A higher incidence of surgeries performed using local anesthesia was reported in the elderly group (p=0.041). Thirty-day surgical complications, according to Clavien-Dindo, did not show significant differences. Conclusion: Despite higher comorbidity and ASA score, breast surgery is safe and feasible in elderly patients. Due to the higher risk of upstaging to invasive ductal carcinoma, surgery should be performed but sentinel lymph node biopsy should be omitted, owing to the low risk of lymph node metastasis and lower use of adjuvant treatments.