RT Journal Article SR Electronic T1 Serum Versus Tissue SIRT1 as Potentially Valuable Biomarkers in Gastric Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1485 OP 1491 DO 10.21873/anticanres.16297 VO 43 IS 4 A1 OTSUKA, RYOTA A1 MORISHITA, HIROKI A1 IIDA, KEIKO A1 HAYANO, KOICHI A1 MURAKAMI, KENTARO A1 ENDO, SATOSHI A1 TOYOZUMI, TAKESHI A1 MATSUMOTO, YASUNORI A1 KURATA, YOSHIHIRO A1 KINOSHITA, KAZUYA A1 SASAKI, TAKUMA A1 IIDA, SHINICHIRO A1 NISHIOKA, YURI A1 MATSUBARA, HISAHIRO YR 2023 UL http://ar.iiarjournals.org/content/43/4/1485.abstract AB Background/Aim: We lack reports on the clinicopathological characteristics and prognostic value of serum sirtuin 1 (SIRT1) levels and their association with SIRT1 expression in tissues of patients with gastric cancer (GC). Thus, we investigated the pathological characteristics and prognostic values of SIRT1 tissue expression and its serum concentration in GC. Moreover, we investigated the correlation between these two factors. Materials and Methods: A total of 78 patients with GC who underwent curative gastrectomy were evaluated in this study. The expression of SIRT1 in the surgical specimens was assessed using immunohistochemistry. Serum levels of SIRT1 were measured using an enzyme-linked immunosorbent assay. The association of tissue and serum SIRT1 with the clinicopathological features and prognosis were evaluated. Results: Positive SIRT1 tissue expression was significantly related to an advanced cancer stage (p=0.017). Furthermore, a significant relationship existed between a positive SIRT1 tissue expression and poorer overall survival (OS) and relapse-free survival (RFS) (p=0.033 and p=0.033, respectively). In contrast, serum SIRT1 levels showed no significant association with clinicopathological characteristics besides age. In addition, no significant correlation was observed between tissue SIRT1 expression and serum SIRT1 concentration. Conclusion: Tissue SIRT1 expression may be a valuable novel prognostic biomarker; nonetheless, further studies are required to clarify the relationship between tissue SIRT1 expression and serum SIRT1 levels in GC.