RT Journal Article SR Electronic T1 Rectus Sheath Block (RSB) Analgesia Could Enhance Significantly the Patient Satisfaction Following Midline Laparotomy in Benign Disease and in Cancer: A Prospective Study With Special Reference to Nitrosative Stress Marker Nitrotyrosine (NT) Plasma Concentrations JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1383 OP 1389 DO 10.21873/anticanres.13252 VO 39 IS 3 A1 VIIVI KUOSMANEN A1 IINA SAIMANEN A1 DINA RAHKOLA A1 JARI KÄRKKÄINEN A1 TUOMAS SELANDER A1 MARTIN PURDY A1 HANNU KOKKI A1 MERJA KOKKI A1 MATTI ESKELINEN YR 2019 UL http://ar.iiarjournals.org/content/39/3/1383.abstract AB Background/Aim: Our hypothesis was that rectus sheath block (RSB) analgesia could enhance satisfaction following midline laparotomy in patients with benign disease and cancer patients. Patients and Methods: Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups. The plasma concentrations of the NT marker were measured just before, immediately after and 24 h after operation. Patient satisfaction at 24 h postoperatively was filed on a 11-point numeric rating scale (SFS24; 0=fully unsatisfied; 10=fully satisfied). Results: The RSB analgesia significantly enhanced the SFS24 scores in the study groups (p=0.001). The median plasma NT concentrations (pg/ml) following surgery (POP1) were significantly lower in patients with cancer versus patients with benign disease (5.3 vs. 7.6, p=0.008). Jitter plots of the individual SFS24 values versus plasma NT concentrations were significantly correlated in benign and cancer patients (r=−0.284, p=0.028). Conclusion: The RSB analgesia could significantly enhance patient satisfaction following midline laparotomy. Plasma NT concentrations versus patient satisfaction following surgery are significantly correlated in benign disease and cancer.